about PSI

With the completion of the sequencing of the genomes of human and other organisms, attention has focused on the characterization and function of proteins, the products of genes. The availability of sequence data and the growing impact of structural biology on biomedical research have prompted scientific groups from several countries to undertake projects in the emerging field of structural genomics. The objective is to make these structures widely available for clinical and basic studies that will expand the knowledge of the role of proteins both in normal biological processes and in disease. The National Institute of General Medical Sciences (NIGMS) played a major role in the early planning for structural genomics and in 1999 organized a national program, the Protein Structure Initiative.

PSI Mission

The long-range goal of the Protein Structure Initiative (PSI) is to make the three-dimensional atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences. Specific goals include:

  • Developing methodology and technology to increase success rates and lower costs of structure determination,
  • Constructing and automating the protein production and structure determination pipeline, and
  • Determining unique protein structures (less than 30% identical in sequence to proteins for which structures had already been determined).

Latest Publications About the PSI

Structural Genomics: Exploring the 3D Protein Landscape
Chen, D.
Biomedical Computation Review, 2010(Winter):11-19.
Read PDF from Biomedical Computation Review

Exploration of uncharted regions of the protein universe
Jaroszewski L, Li Z, et al. (JCSG)
PLoS Biol. 2009 Sep;7(9):e1000205.

Protein Structure Initiative Material Repository: an open shared public resource of structural genomics plasmids for the biological community.
Cormier CY, Mohr SE, et al. (PSI-MR)
Nucleic Acids Res. 2010 Jan;38(Database issue):D743-9.

See more publications about the PSI in the Research Library.

PSI Funding Opportunities

Listed here are active funding opportunities sponsored by the NIGMS/NIH.

Request For Applications

none at this time

Program Announcements

Notices and Policies



none at this time

View expired announcements

PSI Organization

The following links to the National Institute of General Medical Sciences, the NIH component that supports the PSI, provide the organizational details of the PSI-funded centers, steering committee, program staff, and advisory committee.

PSI-2 Centers

PSI-2 Steering Committee and Subcommittees


PSI Advisory Committee

PSI Policies

PSI Policy on Using PSI Structures for a Rolling Critical Assessment of Modeling and Experimental - Computational Hybrid Methods

PSI Policies on Data Release and Sharing of Results and Materials

PSI Policies on Community-Nominated Targets

PSI Reports

Report from the PSI Advisory Committee, Dec 2009 (PDF | 14 Kb)

Opportunities for Structural Genomics Beyond 2010 : Creating Partnerships for the Future, 2009 (PDF | 4.1 Mb)

Report of the Future Structural Genomics Initiatives Meeting, 2009 (HTML)

Report of the Protein Structure Initiative Assessment Panel, 2007 (HTML)

Assessment of the Protein Structure Initiative, 2007 (HTML)


The Protein Structure Initiative Structural Biology Knowledgebase (SBKB) is a Resource Center within the PSI Program. The goal of the Structural Biology Knowledgebase is to turn the products of the Protein Structure Initiative effort into knowledge that is important for understanding living systems and disease.

PSI SBKB staff:

Helen M. Berman (Director, Rutgers University)
Li Chen
James Chun
Margaret J. Gabanyi
David Micallef
Ezra Peisach
Martha Quesada
Raship Shah
Wendy Tao
John Westbrook

PSI Resource Leaders:

Models: Torsten Schwede, Swiss Institute of Bioinformatics/Biozentrum University of Basel
Experimental Data Tracking: David Micallef, Rutgers University
Technology: Paul Adams, Lawrence Berkeley Laboratory
Publications: Wladek Minor, University of Virginia
Material Repository: Josh LaBaer, ASU Biodesign Institute, Arizona State University

PSI SBKB Steering Committee:

Eaton Lattman, Hauptman-Woodward Medical Research Institute (Chair)
Carol Bult, Jackson Labs
Stephen Burley, SGX Pharmaceuticals
Andrzej Joachimiak, Argonne National Laboratory
Wayne Hendrickson, Columbia University
Gaetano Montelione, Rutgers University
Rich Morimoto, Northwestern University
Ward Smith, NIGMS, NIH
Paul Sternberg, California Institute of Technology
Susan Wente, Vanderbilt University
Ian Wilson, The Scripps Research Institute


Explore proteins and this website