research advances

Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.

May 2009

  • featured articles

    • Controlling p53

      Pirh2 promotes the ubiquitylation of the transcriptionally active form of p53 using an unusual two-site interaction strategy.

      Nat. Struc. Mol. Biol. 15, 1334-1342 (2008)

    • Mitotic checkpoint control

      The molecular basis of inhibition of the anaphase-promoting complex/cyclosome revealed.

      Science 323, 1477-1481 (2009)

  • research highlights

    • Snapshots of proteins at work

      Two groups extend the boundaries of in-cell nuclear magnetic resonance spectroscopy.

      Nature 458, 102-105 (2009)

    • PALM reading

      Super-resolution fluorescence microscopy gets a boost in axial resolution from two groups of optics wizards.

      Proc. Natl. Acad. Sci. 106, (2009)

    • The center cut

      PSI investigators highlight their choice of important structural genomics studies.

      PSI-SGKB May 2009

  • technical highlights

    • Improve your cloning efficiency

      New vectors and a step-by-step protocol will make ligation-independent cloning even simpler.

      Methods Mol. Biol. 498, 105-115 (2009)

    • Faster solid-state NMR

      Improved sensitivity for solid-state nuclear magnetic resonance spectroscopy makes this technique useful for large biomolecules.

      Nature Meth. 6, 215-218 (2009)

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