research advances

Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.

July 2010

  • Selected methods highlights from PSI-2 (2005-2010)

    • Introduction

      Ward Smith and Peter Preusch introduce a series of articles highlighting the achievements of the PSI 2005-2010.

    • Cloning techniques

      PSI centers highlight their cloning successes.

    • Expression and purification

      Generation of stable, purified protein is an essential step in the protein production pathway.

    • Protein crystallization

      From automated pipelines to equipment for traditional labs, the PSI has begun to unblock the crystallization bottleneck.

    • Protein crystallography

      The PSI centers have significantly increased the rate of protein structure determination by advancing and automating many of the experimental and computational steps.

    • NMR spectroscopy

      Protein NMR structures can now be solved in days rather than weeks or months.

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