research advances


SBKB [doi:10.1038/fa_sbkb.2010.37]

PSI JCSG center director Ian Wilson introduces the third in a series of articles highlighting the achievements of the PSI in 2005–2010.

In this third edition of our PSI accomplishments series, we focus on the more than 3,000 three-dimensional protein structures that have been deposited by the PSI in the Protein Data Bank since 2005. These results have been organized into six reviews that parallel the PSI Network's scientific goals: 'Achievements and milestones', 'Membrane protein structures enter an exponential growth phase', 'Protein pathways', 'Journey into the expanding protein universe', and 'Scaling up: single organisms and metagenomics'.

As a result of the creative targeting strategies coupled with the high-throughput experimental methods, technologies and pipelines that we discussed in the past two editions of the Structural Genomics Update, the PSI Network alone has deposited nearly 8% of the structures present in the Protein Data Bank, despite its inauguration only ten years ago. Many of these structures have been leveraged as three-dimensional templates for more than 300,000 computational models. Each of the large-scale centers also had their own biomedical/biological themes, which enabled specific topics to be explored in more depth and facilitated interaction with the broader biological and biomedical community. The specialized centers focused on further areas of interest to the PSI that included methodology and technology development, membrane proteins and eukaryotic proteins.

And related to the topic of biological impact, you will notice that starting this month the Structural Genomics Knowledgebase is changing its name to the Structural Biology Knowledgebase ( in keeping with the recent launch of PSI:Biology. This metamorphosis signals our commitment to juxtapose our efforts more closely with those of the biological community so that we can successfully address important challenges and exciting new developments in biomedical and biological research.

This series of reviews is coordinated by Nature editor Maria Hodges and edited by me with valuable input and comments from many of the other PSI center directors. I hope you enjoy reading about these structures with as much excitement as we had in solving them.

Ian A Wilson


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